Dosage and Administration

Adults: 40-80 mg (1-2 tablets) 2-3 times a day. The maximum daily dose - 240 mg.

Children aged 3 to 6 years of age - a single dose of 20 mg, the maximum daily dose - 120 mg (2-3 hours); aged 6 to 12 years of single - 40 mg, the maximum daily dose - 200 mg; multiplicity of application - 2-5 times a day.

Side effect

Dizziness, headache, insomnia, palpitations, blood pressure, allergic reactions, nausea, constipation, sensation of heat, sweating

Storage conditions

In a dry, dark place at a temperature no higher than 25°C.

Keep out of the reach of children.

Shelf life

3 years.

PARACETAMOL TABLETS BP 500mg

Composition

Each tablet contains 500mg Paracetamol PhEur.

Indications

For the relief of mild to moderate pain and febrile conditions, e.g. headache, toothache, colds, influenza, rheumatic pain and dysmenorrhoea.

Dosage and administration

For oral administration.

Adults including the elderly and children over 16 years: One to two tablets every 4-6 hours as required, to a maximum of 8 tablets daily in divided doses.

Children 10-15 years: One tablet every 4-6 hours as necessary to a maximum of 4 doses in 24 hours.

Children under 10 years: Not recommended for children under 10 years of age. Alternative presentations of paracetamol are recommended for paediatric usage in order to obtain suitable doses of less than 500mg.

Contraindications

Hypersensitivity to the active substance or to any of the excipients.

Special warnings and precautions for use

Where analgesics are used long-term (>3 months) with administration every two days or more frequently, headache may develop or worsen. Headache induced by overuse of analgesics (MOH medication-overuse headache) should not be treated by dose increase. In such cases, the use of analgesics should be discontinued in consultation with the doctor.

Interaction

• Anticoagulants - the effect of warfarin and other coumarins may be enhanced by prolonged regular use of paracetamol with increased risk of bleeding. Occasional doses have no significant effect.

• Metoclopramide – may increase speed of absorption of paracetamol.

• Domperidone – may increase speed of absorption of paracetamol.

• Colestyramine – may reduce absorption if given within one hour of paracetamol.

• Imatinib - restriction or avoidance of concomitant regular paracetamol use should be taken with imatinib.

Undesirable effects

Adverse effects of Paracetamol are rare but hypersensitivity including skin rash may occur.

There have been reports of blood dyscrasias including thrombocytopenia, neutropenia, pancytopenia, leukopenia and agranulocytosis but these were not necessarily causality related to Paracetamol.

Overdose

Liver damage is possible in adults who have taken 10g or more of Paracetamol.

Shelf life

3 years

Storage

Store below 25°C in a dry place. Protect from light.

AMOXIL® (amoxicillin)

• Capsules: 250 mg, 500 mg

• Tablets: 500 mg, 875 mg

• Powder for Oral Suspension: 125 mg/5 ml, 200 mg/5 ml, 250 mg/5ml, 400 mg/5 ml (3)

INDICATIONS

AMOXIL is a penicillin-class antibacterial indicated for treatment of infections due to susceptible strains of designated microorganisms.

• Infections of the ear, nose, throat, genitourinary tract, skin and skin structure, and lower respiratory tract.

• In combination for treatment of H. pylori infection and duodenal ulcer disease.

DOSAGE AND ADMINISTRATION

In adults, 750-1750 mg/day in divided doses every 8-12 hours.

In Pediatric Patients > 3 Months of Age, 20-45 mg/kg/day in divided doses every 8-12 hours.

• Treatment of gonorrhea is 3 grams as a single oral dose.

• The upper dose for neonates and infants ≤ 3 months is 30 mg/kg/day divided every 12 hours.

• Dosing for H. pylori Infection: Triple therapy: 1 gram AMOXIL, 500 mg clarithromycin, and

30 mg lansoprazole, all given twice daily (every 12 hours) for 14 days. Dual therapy: 1 gram AMOXIL and 30 mg lansoprazole, each given three times daily (every 8 hours) for 14 days.

CONTRAINDICATIONS

• History of a serious hypersensitivity reaction (e.g., anaphylaxis or Stevens-Johnson syndrome) to AMOXIL or to other beta-lactams (e.g. penicillins or cephalosporins)

WARNINGS AND PRECAUTIONS

• Anaphylactic reactions: Serious and occasionally fatal anaphylactic reactions have been reported in patients on penicillin therapy. Serious anaphylactic reactions require immediate emergency treatment with supportive measures.

• Clostridium difficile-associated diarrhea (ranging from mild diarrhea to fatal colitis): Evaluate if diarrhea occurs.

ADVERSE REACTIONS

The most common adverse reactions (>1%) observed in clinical trials of AMOXIL capsules, tablets or oral suspension were diarrhea, rash, vomiting, and nausea.

DRUG INTERACTIONS

• Probenicid decreases renal tubular secretion of amoxicillin, which may result in increased blood levels of amoxicillin.

• Concomitant use of AMOXIL and oral anticoagulants may increase the prolongation of prothrombin time.

• Coadministration with allopurinol increases the risk of rash.

• AMOXIL may reduce the efficacy of oral contraceptives.

STORAGE

Store at or below 25°C

OTIBRU

Composition of drug :

Active ingredients:1 g of preparation contains 40 mg phenazone and 10 mg lidocaine hydrochloride;

Excipients: sodium thiosulfate, ethanol, glycerol, purified water.

Pharmacological group. Combination drug for use in otology.

Pharmacological properties. Strong analgesic/anti-inflammatory effect. The action of drug (relieving of tympanum pain and reduction of inflammation) starts 5 minutes after the instillation. The pain disappears within 15–30 minutes.

Indications for use. Local symptomatic treatment and analgesia in:

- acute medium otitis;

- otitis as a complication after flu;

- barotraumatic otitis.

Contraindications. Infectious or traumatic injury of the tympanic membrane. Hypersensitivity to lidocaine or other components of the drug.

Precautions.

Before instilling the drug, it is necessary to check integrity of membrane tympani. If tympanic membrane is perforated, instillation of the drug may lead to contact with medium ear structures and therefore may cause adverse effects.

There are no data about contraindications for using the drug in pregnancy or breastfeeding.

The drug does not affect possibility to drive or operate machinery.

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