Dosage - Reserved for Adults:

Place one capsule deep in the vagina for 12 ours. It is preferable and easier to insert the capsule while lying down on your back with the knees apart.

Practical advice:

• to avoid contaminating the people around you, use your own face cloth and towel

• wear cotton underwear

• avoid vaginal douches

• avoid using tampons during treatment

• do not stop treatment during menstrual periods

• your physician may also treat your sexual partner in order to avoid reinfection.

Storage Conditions:

Use before the expiry date indicated on the external packaging. Store below 25°C.

DO NOT SWALLOW. KEEP OUT OF THE REACH AND SIGHT OF CHILDREN.

Lagaay International BV

Van Helmontstraat 99

3029 AA Rotterdam,

The Netherlands

Tel: +31 - 10 4123871

SEPTOZYL

Cream with Neomycin

Topical corticoid for use in skin diseases

Composition

Each one gram of cream contains:

5 mg Neomycin sulfate

1 mg 9a-fluoro-16a-methylprednisolon

Septozyl cream is effective for topical use in skin diseases. The first active substance — a synthetic corticoid ester — has an anti-inflammatory and anti-allergic action, and the second component Neomycin sulfate has antibacterial activity. This composition is available in a specially formulated base, which is excellently tolerated by the skin. Septozyl cream is suitable for use in adults and children.

Indications

Eczema of varying type and localization, including infantile eczema. Various forms of dermatitis, sunburn, otitis externa, intertrigo and napkin rash. Various forms of neurodermatitis. Skin diseases especially psoriasis, lichen planus and chronic discoid lupus erythematosus. Itching of the pudenda and anus.

Application and dosage

Septozyl should be applied to the skin in a thin film several times daily. In some cases, one application a day will prove sufficient. After the skin has healed, Septozyl with neomycin should be applied one time daily for a further 1—2 weeks in order to prevent any recurrence of the disease.

Side effects

After a long-term use of Septozyl, and when the preparation is applied to extensive areas of skin, there is a possibility of the following side effects appearing:

1) hyperglycaemia and glycosuria (in patients with a family history of diabetes mellitus);

2) increased potassium excretion, possibly resulting in hypokalaemic alkalosis;

1) hypertrichosis and acne;

2) sodium and water retention, giving rise to oedema and hypertension,

3) a negative nitrogen balance;

4) clinical picture of Cushing’s syndrome;

7) delayed healing of surgical wounds;

8) prolonged treatment may cause adrenocoptical atrophy.

Contraindications

- Pregnancy, particularly during the first three months.

- Severe renal diseases (excluding nephrosis).

- Psychoses, or a tendency to phychosis.

- Active tuberculosis.

- Infectious diseases.

- Tendency to haemorrage (in patients with peptic ulcer).

Drugs should be kept out of the reach of children. Tel. No. of centre for poisoning cases: 7793777.

Packs: Cream in tubes of 15 g.

TOBRADEX® ST (tobramycin / dexamethasone ophthalmic suspension) 0.3%/0.05%

COMPOSITION

TOBRADEX® ST ophthalmic suspension contains 3 mg/ml tobramycin and 0.5 mg/ml dexamethasone.

INDICATIONS

TOBRADEX® ST is a topical antibiotic and corticosteroid combination for steroid-responsive inflammatory ocular conditions for which a corticosteroid is indicated and where superficial bacterial ocular infection or a risk of bacterial ocular infection exists.

DOSAGE AND ADMINISTRATION

Instill one drop into the conjunctival sac(s) every 4 to 6 hours. During the initial 24 to 48 hours, dosage may be increased to one drop every 2 hours. Frequency should be decreased gradually as warranted by improvement in clinical signs, but care should be taken not to discontinue therapy prematurely.

CONTRAINDICATIONS

TOBRADEX® ST, as with other ophthalmic corticosteroids, is contraindicated in most viral diseases of the cornea and conjunctiva including epithelial herpes simplex keratitis (dendritic keratitis), vaccinia, and varicella, and also in mycobacterial infection of the eye and fungal diseases of ocular structures.

Hypersensitivity to any component of the medication.

WARNINGS AND PRECAUTIONS

Prolonged use of corticosteroids may result in glaucoma with damage to the optic nerve, defects in visual acuity and fields of vision. If this product is used for 10 days or longer, intraocular pressure (IOP) should be monitored.

Prolonged use of corticosteroids may suppress the host response and thus increase the hazard of secondary ocular infections.

Use of ocular steroids may prolong the course and may exacerbate the severity of many viral infections of the eye (including herpes simplex).

Fungal infections of the cornea are particularly prone to develop coincidentally with long-term local steroid application. Fungus invasion must be considered in any persistent corneal ulceration where a steroid has been used or is in use.

ADVERSE REACTIONS

Most common adverse reactions to topical ocular tobramycin are hypersensitivity and localized ocular toxicity, including eye pain, eyelids pruritus, eyelid edema, and conjunctival hyperemia. The reactions due to the steroid component are increases in intraocular pressure with possible development of glaucoma.

MUCOLYTE

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