Title should reflect the subject, the topic and the main goal of the article.

AUTHORS

Firstnameone I. Lastnameone¹, Firstnametwo I. Lastnametwo², Firstnamethree I. Lastnamethree^{1, 3}, …, ….

Affiliations

¹Author’s workplace (University/Research Institute, City, Country)

²Another author’s workplace (University/Research Institute, City, Country)

³etc.…

Structured abstract

Abstract shouldn’t be less than 150 words and more than 350 words.

Background: The short description (not more than 1-3 sentences) of the challenge caused the research. Scale, effects and research gaps of the challenge could be described here.

Aim: The main goal of the research should be described.

Methods: Describe the research design, object of analysis, medical procedure characteristics, research duration, onset, and estimation methods of the research.

Results: In this section the research sample (enrolled participants) should be described shortly as well as the research results estimation. In a study including groups, the description of the primary finding(s) should be supplemented with an analysis of the detected differences between the groups. Any undesirable phenomena occurring during the research should be mentioned obligatory.

Conclusion: The summary of the research (not more than 1-3 sentences) without using generalizations; an author should keep the balance between positive and negative estimations of research results.

Key words: Term 1; term 2; term 3. Minimum – 3, maximum – 7 key words. Key words should be chosen only from MeSH thesaurus (http: //www.ncbi.nlm.nih.gov/mesh)

Background

Author should state the research question, describe its relevance, scale (prevalence, incidence, etc.), indirect effects (social and economic one), and define resolved and unresolved aspects of the issue analyzing previously published data.

Each statement excluding generally known ones should have references (no more than 3 for each statement).

Aim

In this section the main objective of the research should be formulated.

Methods

Research design

Author in this section should define the design of a study and report the study type, its duration, enrollment procedure, supposed medical intervention, research question, hypotheses, independent and dependent variables, experimental design, and, if applicable, data collection methods and statistical analysis plan. Randomized research requires a detailed description of randomization procedure.

Conformity criteria

Author should mention and describe if necessary the set of criteria (formulated before the study) for inclusion, non-inclusion, and exclusion criteria.

Research facilities

Authors should provide detailed information on the venue of the research, indicating the location and departmental affiliation of the center taking part in the research. Along with the venue for the research, authors should clarify some specific factors (social, economic, cultural) that can influence the external generalizability of the research findings.

Research duration

This section provides details about the planned study duration and its intermediate checkpoints (the description should be full enough). Any possible changes in plans should be described properly.

Medical procedure description

The whole procedure should be described in details: any manipulations with participants/respondents, their tissues or data; experimental administration of medical agents; blood tests; questionnaires, etc. Surgical interventions require full description of the peculiarities of preoperative preparation, surgery itself and postoperative patient management. If the manuscript reports the results of non-drug medical procedure its description is also necessary.

Research findings

The main research outcome

In this section the description of the primary endpoints should be made. They could be “true” (lethal outcome, serious adverse effects, etc.) or “substitute” finishing point (biochemical parameters, quality of life assessment scores). Usually the main outcome of the research is characterized by safety, efficiency, and affordability.

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